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Heparin-Binding Protein (HBP), a neutrophil-derived granule protein, serves as an early diagnostic biomarker for infectious diseases, particularly severe bacterial infections. Serum/plasma HBP levels rise significantly in bacterial infections, whereas non-bacterial infections do not induce such an elevation.
Heparin-Binding Protein (HBP) is applied for the early identification, risk stratification, and prognosis assessment of severe bacterial infections and sepsis, as well as the differential diagnosis of acute inflammatory conditions and localized infection-induced vascular leakage.
HBP OEM kit utilizes a two-antibody sandwich immunoassay and is applicable to chemiluminescence platforms. Specific monoclonal antibodies target distinct structural epitopes on the HBP molecule to capture plasma or serum HBP, delivering high sensitivity and exceptional specificity without cross-reactivity to other neutrophil granule proteins. Calibrated with high-purity recombinant HBP antigen, the assay provides accurate, reliable, and stable quantitative results. Serving as an early-warning biomarker for acute vascular leakage and organ failure, it supports timely clinical intervention, triage in emergency and intensive care units (ICU), and dynamic therapeutic efficacy monitoring in severe infectious diseases.
★Bulk reagents are available with matching raw materials.
Marca :
QYM,SURFTECHArtículo n.° :
HBP-1Pedido (MOQ) :
On requestPago :
T/TOrigen del producto :
ChinaColor :
R1 should be a colorless to pale yellow transparent liquid; R2 should be a milky white suspension.Puerto de embarque :
Hefei or other portsPlazo de entrega :
On requestPeso :
On requestHBP OEM reagent
Product Specifications
| Product Name | HBP OEM reagent (chemiluminescence platforms) |
| Application: | It is applied for the early identification, risk stratification, and prognosis assessment of severe bacterial infections and sepsis, as well as the differential diagnosis of acute inflammatory conditions and localized infection-induced vascular leakage. |
| Detection Principle |
Two-antibody sandwich immunoassay |
|
Sample Type: |
Plasma (non-heparin anticoagulated plasma) |
|
Calibrator Component: |
Recombinant HBP |
|
Method |
Acridinium Ester Chemiluminescence |
|
Sample Volume |
10 μL |
|
Linear Range |
2.0–200 ng/mL |
|
LOB |
0.1 ng/mL |
|
Accuracy |
Recovery 85%–115% |
|
Reference interval |
≤10 ng/mL |
|
Precision |
Intra-assay CV ≤5%; Inter-assay CV ≤10% |
|
Method comparison |
Correlation coefficient r＞0.975 vs. Axsi-Shield |
|
Interferents |
Bilirubin: <20 mg/dL; Hemoglobin: <5000 mg/L;Triglycerides: <10 mmol/L; Rheumatoid Factor: <500 IU/mL |
| Hook | 2000 ng/mL |
| Package Size |
on request |
| Storage/Shipping | Store sealed and protected from light at 2 °C to 8 °C |
| Shelf Life | 12 months |
Product Advantages
1.Higher sensitivity than mainstream reagents.
2.Excellent linearity ≤200 ng/mL.
3.Precision within 5% across all concentrations.
4.Reliable long-term stability under specified storage conditions (heat degradation test).
5.Good correlation versus Axis-Shield reagents.
Sensitivity Analysis Batch precision test
Linear Range Validation Thermal Damage Test
Application Scenarios
Heparin-Binding Protein (HBP), a neutrophil-derived granule protein, serves as an early diagnostic biomarker for infectious diseases, particularly severe bacterial infections. Serum/plasma HBP levels rise significantly in bacterial infections, whereas non-bacterial infections do not induce such an elevation.
Heparin-Binding Protein (HBP) is applied for the early identification, risk stratification, and prognosis assessment of severe bacterial infections and sepsis, as well as the differential diagnosis of acute inflammatory conditions and localized infection-induced vascular leakage.
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FAQ
Does HBP detect bacterial infection and sepsis earlier than PCT and CRP?
Yes. HBP is rapidly released from neutrophil secretory vesicles within 1–2 hours of bacterial stimulus—reaching peak levels up to 12–24 hours earlier than PCT or CRP, providing a crucial window for early sepsis detection and vascular leakage prediction.
Can the assay reliably differentiate severe bacterial infections from viral or non-infectious systemic inflammation?
Yes. HBP levels rise marked only in response to intact bacteria or bacterial cell wall components (e.g., LPS), remaining low or normal in viral infections, viral pneumonia, or aseptic inflammatory conditions.
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